By Prof. Dr. med. Heinz Grefor Wieser (auth.), B. Sutter, O. Schröttner (eds.)
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Additional resources for Advances in Epilepsy Surgery and Radiosurgery
Acta Neurol Scand 95: 129-136 57. Milner B (1975) Psychological aspects of focal epilepsy and its neurosurgical management. Adv Neurol8: 299-321 58. O'Brien n, So EL, Mullan BP, Cascino GD, Hauser MF, Brinkmann BH, Sharbrough FW, Meyer FB (2000) Subtraction peri-ictal SPECT is predictive of extra temporal epilepsy surgery outcome. Neurology 55: 1668-1677 59. O'Brien n, So EL, MulIan BP, Hauser MF, Brinkmann BH, Bohnen NI, Hanson D, Cascino GD, Jack CRJ, Sharbrough FW (1998) Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus.
Had to be chosen and, together with strict selection of patients, were obviously of crucial importance to success. In March 1993 the first patient with medically refractory mesial temporal lobe epilepsy was treated by Gamma Knife surgery in Marseilles . Instead of a microsurgical procedure, an entorhinoamygdalohippocampectomy was performed with the Gamma Knife at low marginal dose (25 Gy). The patient has been seizure-free since the day of treatment without any clinical complication .
Experimental studies have shown biochemical differential effect of radiosurgery on the striatum, glial cell elimination, stem cell migration toward the target area, sprouting, ... Plasticity phenomenon are induced by radiosurgery when using non necrotizing dosemetry. Discussion. There is clinical and experimental evidence of Gamma Knife capability to induce modulation in the neural system. Detailed mechanism of this modulation and dosemetric parameters enabling to induce such plasticity with no necrosis are still unknown.
Advances in Epilepsy Surgery and Radiosurgery by Prof. Dr. med. Heinz Grefor Wieser (auth.), B. Sutter, O. Schröttner (eds.)